In Gotham City, mentally troubled comedian Arthur Fleck is disregarded and mistreated by society. He then embarks on a downward spiral of revolution and bloody crime. This path brings him face-to-face with his alter-ego: the Joker.
A daring synthetic biologist, after a car accident kills his family, will stop at nothing to bring them back, even if it means pitting himself against a government-controlled laboratory, a police task force and the physical laws of science.